2nd Edition of Cosmetology Aging and Rejuvenation World Conference 2026

Abstract

This study focuses on the development of innovative hydrogel nanocomposites from biocompatible, natural materials to rejuvenate skin and mitigate the aging process. Two distinct hydrogel nanocomposites were formulated to combat both internal and external factors contributing to skin aging. The first formulation consists of hyaluronic acid, starch, ascorbic acid, and selenium-enriched microalgae, enhanced with chitosan and polyethylene glycol. The second formulation includes chitosan, collagen, and Origanum vulgare extract, recognized for their restorative and anti-aging properties. Key parameters, including polymer concentration, temperature, pH, and antibacterial efficacy, were systematically evaluated, and optimization was performed using Response Surface Methodology (RSM). Both formulations demonstrated remarkable moisture absorption capabilities (85% and 75%) and exhibited significant antibacterial activity against Gram-positive bacteria (90% and 85%). Advanced analytical techniques confirmed the chemical integrity and biocompatibility of the nanocomposites. Notably, the first formulation presented a particle size of approximately 148 nm, robust moisture retention, and considerable antibacterial effectiveness against Staphylococcus aureus. The formulations were rigorously validated through comprehensive analyses, affirming their potential for dermatological applications. When successfully incorporated into a semi-solid cream with an oil-in-water emulsion base, these nanocomposites exhibit promising physicochemical characteristics. This research emphasizes the potential of these innovative formulations for clinical use in skin-rejuvenation products and recommends future investigations to explore their applicability in various topical formulations, such as serums, lotions, and sunscreens.